2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

Base Information

Chemical Name:2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide
CAS No.:1590397-87-7
Molecular Formula:C₁₅H₁₅F₃N₄O
Molecular Weight:324.306
Hs Code.:

Synonyms:2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

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Chemical Property of 2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

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Technology Process of 2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

There total 5 articles about 2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1590397-86-6
tert-butyl methyl(2-oxo-2-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methylamino)ethyl)carbamate

: 1590397-87-7
2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1590397-87-7
2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water; ethanol / 7 h / 130 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 2 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / 3 h / 2585.81 Torr

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

5: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;

Reference yield:

: 1257437-45-8
6-(4-(trifluoromethyl)phenyl)pyrimidine-4-carbonitrile

: 1590397-87-7
2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / 3 h / 2585.81 Torr

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;