{(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol

Base Information

• Chemical Name: {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol
• CAS No.: 1587727-57-8
• Molecular Formula: C₁₃H₁₅F₃O₂
• Molecular Weight: 260.256

Synonyms:{(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol

Chemical Property of {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol

Chemical Property:

Purity/Quality:

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Technology Process of {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol

There total 2 articles about {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

{(2S,3S,5R)-3-(Iodomethyl)-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methyl pivalate → {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol (1587727-57-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1002/ejoc.201801318

Reference yield:

tert-butyl({(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)diphenylsilane (1587727-56-7) → {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol (1587727-57-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; n-heptane; tert-butyl methyl ether; ethyl acetate;

Reference yield:

{(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methanol (1587727-57-8) → {(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methyl methanesulfonate (1587727-58-9)

Guidance literature:

upstream raw materials:

tert-butyl({(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)diphenylsilane

Downstream raw materials:

{(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methyl methanesulfonate

2-[({(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methyl)amino]ethanol

7-(4-methyl-1H-imidazol-1-yl)-2-({(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

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