(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Base Information

Chemical Name:(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol
CAS No.:134744-46-0
Molecular Formula:C₃₁H₅₀O₅Si
Molecular Weight:530.82
Hs Code.:

Synonyms:(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

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Chemical Property of (2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

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Technology Process of (2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

There total 8 articles about (2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 123493-58-3
(2S,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptanal

: 134744-46-0
(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -50 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(01)96139-3

Reference yield:

: 114114-16-8
(2R,4R)-4-Benzyloxy-2,4-dimethyl-hex-5-enal

: 134744-46-0
(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.5 h / -50 °C

2: imidazole / dimethylformamide / 12 h / 25 °C

3: 1) O₃, pyridine, Sudan IV, 2) Me₂S / 1) CH₂Cl₂, -78 deg C, 2) up to 25 deg C, 1 h

4: 16 percent / MgBr₂ / CH₂Cl₂ / 50 h / 25 °C

5: 1) NaH / 1) DMF, 25 deg C

6: 1) O₃, pyridine, Sudan IV, 2) Me₂S / 1) CH₂Cl₂, -78 deg C, 2) up to room temp., 1.5 h

7: 100 percent / LiAlH₄ / diethyl ether / 0.33 h / -50 °C

With pyridine; 1H-imidazole; 1-[{2-methyl-4-(2-methylphenylazo)-phenyl}-azo]-2-naphthalenol; lithium aluminium tetrahydride; dimethylsulfide; sodium hydride; ozone; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96139-3

Reference yield:

: 114114-17-9
(3R,5R)-3-benzyloxy-6-tert-butyldimethylsiloxy-3,5-dimethylhex-1-ene

: 134744-46-0
(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 1) O₃, pyridine, Sudan IV, 2) Me₂S / 1) CH₂Cl₂, -78 deg C, 2) up to 25 deg C, 1 h

2: 16 percent / MgBr₂ / CH₂Cl₂ / 50 h / 25 °C

3: 1) NaH / 1) DMF, 25 deg C

4: 1) O₃, pyridine, Sudan IV, 2) Me₂S / 1) CH₂Cl₂, -78 deg C, 2) up to room temp., 1.5 h

5: 100 percent / LiAlH₄ / diethyl ether / 0.33 h / -50 °C

With pyridine; 1-[{2-methyl-4-(2-methylphenylazo)-phenyl}-azo]-2-naphthalenol; lithium aluminium tetrahydride; dimethylsulfide; sodium hydride; ozone; magnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)96139-3