N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

Base Information

Chemical Name:N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride
CAS No.:634904-52-2
Molecular Formula:C₂₆H₂₄N₄O₃S*ClH
Molecular Weight:509.029
Hs Code.:

Synonyms:N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

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Chemical Property of N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

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Technology Process of N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

There total 10 articles about N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide

: 634904-52-2
N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide

: 634904-52-2
N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane; water

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 18 h / 60 °C

3: hydrogenchloride / water; acetonitrile

5: hydrogenchloride / water

With hydrogenchloride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; acetonitrile;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide hydrochloride

: 634904-52-2
N-[3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)phenyl]-5-isoxazolecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 18 h / 60 °C

2: hydrogenchloride / water; acetonitrile

4: hydrogenchloride / water

With hydrogenchloride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); water; acetonitrile;