{N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

Base Information

Chemical Name:{N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester
CAS No.:119688-96-9
Molecular Formula:C₂₂H₃₆N₈O₄Si
Molecular Weight:504.665
Hs Code.:

Synonyms:{N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

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Chemical Property of {N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

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Technology Process of {N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

There total 8 articles about {N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 119688-95-8
{N'-[(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3,6-dihydroxy-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

: 119688-96-9
{N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

Guidance literature:: With hydrogen azide; triphenylphosphine; diethylazodicarboxylate; In acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)80421-9

Reference yield: 65.0%

: 942292-44-6
C₁₂H₂₄N₆O₃Si

: 55501-33-2
benzyl 2-(1-methylhydrazinyl)acetate

: 119688-96-9
{N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

Guidance literature:: C₁₂H₂₄N₆O₃Si; With chloroformic acid ethyl ester; triethylamine; In toluene; at -5 ℃;

benzyl 2-(1-methylhydrazinyl)acetate; In toluene; Further stages.;
DOI:10.1016/j.tetlet.2007.03.169

Reference yield:

: 58475-20-0
3,5-dideoxy-1,2-O-isopropylidene-α-D-erythro-hexofuranose

: 119688-96-9
{N'-[(3R,5R)-3,6-Diazido-5-(tert-butyl-dimethyl-silanyloxy)-hexanoyl]-N-methyl-hydrazino}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaIO₄ / RuO₄ / CCl₄; acetonitrile; H₂O

2: 79 percent / isobutyl chloroformate / tetrahydrofuran / -10 °C

3: Dowex AG 50W X₄ ion exchange resin H(+) form / H₂O / 0.5 h / 60 °C

4: 50.4 percent / 1,2-dichloro-ethane; pyridine / 120 h

5: 80 percent / NaBH₄ / acetic acid; ethanol / 0 °C

6: 70 percent / triphenylphosphine, hydrazoic acid, diethyl azodicarboxylate / benzene; acetonitrile

With sodium tetrahydroborate; sodium periodate; hydrogen azide; Dowex AG 50W X₄ ion exchange resin H(+) form; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; ruthenium tetroxide; In tetrahydrofuran; pyridine; tetrachloromethane; ethanol; water; acetic acid; 1,2-dichloro-ethane; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)80421-9