(S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate

Base Information

• Chemical Name: (S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate
• CAS No.: 1357190-79-4
• Molecular Formula: C₁₅H₁₆N₂O₆Si
• Molecular Weight: 348.387
• Mol file: 1357190-79-4.mol

Synonyms:(S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate

Chemical Property of (S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate

There total 2 articles about (S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)‐5‐(trimethylsilyl)pent‐1‐en‐4‐yn‐3‐ol (488791-22-6) + 3,5-dinitrobenoyl chloride (99-33-2) → (S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate (1357190-79-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.01.007

Reference yield:

trimethylsilylacetylene (1066-54-2) → (S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate (1357190-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethylzinc / toluene / 1 h / 100 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: 18 h / 20 °C

2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With diethylzinc; triethylamine; In dichloromethane; toluene;

DOI:10.1016/j.tetasy.2013.01.007

Reference yield: 87.0%

(S)-1-(trimethylsilyl)pent-4-en-1-yn-3-yl 3,5-dinitrobenzoate (1357190-79-4) → (S)-5-bromo-1-penten-4-yn-3-yl 3,5-dinitrobenzoate

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 0 - 25 ℃; for 5h; Inert atmosphere; Schlenk technique; Darkness;

DOI:10.1016/j.tetasy.2015.12.001

upstream raw materials:

(S)‐5‐(trimethylsilyl)pent‐1‐en‐4‐yn‐3‐ol

3,5-dinitrobenoyl chloride

trimethylsilylacetylene