1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

Base Information

Chemical Name:1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine
CAS No.:1318768-38-5
Molecular Formula:C₃₉H₃₆N₂O₈S₂
Molecular Weight:724.855
Hs Code.:

Synonyms:1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

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Chemical Property of 1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

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Technology Process of 1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

There total 4 articles about 1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1318768-37-4
1-[2-thio-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1318768-38-5
1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

Guidance literature:: With pyridine; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c1ob05469d

Reference yield:

: 1209008-56-9
C₁₁H₁₄N₂O₅S₂

: 1318768-38-5
1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / N,N-dimethyl-formamide / 15 h / 100 °C / Inert atmosphere

2: dichloromethane / 0.5 h / 20 °C / Photoirradiation

3: pyridine / 1 h / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 48 h / 20 °C

5: pyridine / 3 h / 20 °C / Inert atmosphere

With pyridine; dmap; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05469d

Reference yield:

: 1318768-34-1
1-[2-thio-3,5-di-O-(tert-butyldiphenylsilyl)-2-S,4-C-(1-thiaethylene)-β-D-ribofuranosyl]thymine

: 1318768-38-5
1-[2-thio-5-O-(4,4'-dimethoxytrityl)-2-S,4-C-{(R)-(benzoylsulfanyl)methylene}-β-D-ribofuranosyl]thymine

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0.5 h / 20 °C / Photoirradiation

2: pyridine / 1 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 48 h / 20 °C

4: pyridine / 3 h / 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c1ob05469d