(2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

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Chemical Name:(2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester
CAS No.:619325-21-2
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

Synonyms:(2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

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Chemical Property of (2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

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Technology Process of (2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

There total 4 articles about (2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 619324-93-5
3-[4-[[[2-(3-quinolinyl)ethyl]amino]methyl]phenyl]-(2E)-2-propenoic acid methyl ester

: 619325-21-2
(2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 60 ℃; for 17h;
DOI:10.1021/jm030235w

Reference yield:

: 21863-57-0
3-quinolineacetonitrile

: 619325-21-2
(2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂; TFA / Pd/C / methanol / 3 h

2: 78 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

3: 38 percent / DIEA / dimethylsulfoxide / 17 h / 60 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm030235w

Reference yield:

: 7560-50-1,71093-79-3,58045-41-3
methyl (2E)-3-(4-formylphenyl)acrylate

: 619325-21-2
(2E)-3-[4-([(2-quinolin-3-ylethyl)-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

2: 38 percent / DIEA / dimethylsulfoxide / 17 h / 60 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm030235w