2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

Base Information

Chemical Name:2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid
CAS No.:1436851-29-4
Molecular Formula:C₂₆H₂₇ClN₆O₅
Molecular Weight:538.991
Hs Code.:

Synonyms:2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

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Chemical Property of 2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

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Technology Process of 2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

There total 9 articles about 2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1436851-28-3
C₂₈H₃₁ClN₆O₅

: 1436851-29-4
2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

Guidance literature:: With hydrogenchloride; lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h; pH=6 - 7;
DOI:10.1021/jm400463q

Reference yield:

: 554-84-7
meta-nitrophenol

: 1436851-29-4
2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: iron; ammonium chloride / water; tetrahydrofuran / 3 h / 65 °C / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

4: trifluoroacetic acid / iso-butanol / 3 h / 100 °C / Reflux

5: lithium hydroxide; hydrogenchloride / water; tetrahydrofuran / 1 h / 0 - 20 °C / pH 6 - 7

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; iso-butanol;
DOI:10.1021/jm400463q

Reference yield:

: 76661-24-0
2,5-dichloro-4-(3-nitrophenoxy)pyrimidine

: 1436851-29-4
2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iron; ammonium chloride / water; tetrahydrofuran / 3 h / 65 °C / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

3: trifluoroacetic acid / iso-butanol / 3 h / 100 °C / Reflux

4: lithium hydroxide; hydrogenchloride / water; tetrahydrofuran / 1 h / 0 - 20 °C / pH 6 - 7

With hydrogenchloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; iso-butanol;
DOI:10.1021/jm400463q