7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

Base Information

Chemical Name:7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one
CAS No.:1246251-30-8
Molecular Formula:C₂₅H₂₅N₃O₄
Molecular Weight:431.491
Hs Code.:

Synonyms:7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

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Chemical Property of 7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

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Technology Process of 7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

There total 8 articles about 7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.4%

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 1246251-13-7
2-(2,6-dimethyl-pyridin-4-yl)-7-fluoro-5-methoxy-3H-quinazolin-4-one

: 1246251-30-8
7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

Guidance literature:: 2-Benzyloxyethanol; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.333333h;

2-(2,6-dimethyl-pyridin-4-yl)-7-fluoro-5-methoxy-3H-quinazolin-4-one; In dimethyl sulfoxide; mineral oil; at 85 ℃; for 24h;

Reference yield:

: 1073-23-0
2,6-lutidine N-oxide

: 1246251-30-8
7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: ammonium persulfate / water / 16 h / Inert atmosphere; Reflux

3.1: manganese(IV) oxide / ethanol / 17 h / Reflux

4.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 115 °C

5.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.33 h / 20 °C

6.2: 24 h / 85 °C

With manganese(IV) oxide; ammonium persulfate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; In ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1246249-28-4
2-(2,6-dimethyl-pyridin-4-yl)-5,7-difluoro-3H-quinazolin-4-one

: 1246251-30-8
7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.33 h / 20 °C

2.2: 24 h / 85 °C

With sodium methylate; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;