(+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

Base Information

Chemical Name:(+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol
CAS No.:128631-54-9
Molecular Formula:C₂₂H₃₃ClN₄O₄
Molecular Weight:452.981
Hs Code.:

Synonyms:(+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

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Chemical Property of (+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

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Technology Process of (+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

There total 5 articles about (+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128631-53-8
(+/-)-1-amino-5-(benzyloxy)pentan-3-ol

: 97570-32-6
2-(2-amino-4,6-dichloropyrimidin-5-yl) acetaldehyde diethyl acetal

: 128631-54-9
(+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

Guidance literature:: With triethylamine; In butan-1-ol; at 100 ℃; for 72h;
DOI:10.1021/jm00171a022

Reference yield:

: 70388-33-9
4-benzyloxybut-1-ene

: 128631-54-9
(+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 95 percent / Et₂AlCl / hexane / Ambient temperature

3: 58 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

4: 8.35 g / Et₃N / butan-1-ol / 72 h / 100 °C

With lithium aluminium tetrahydride; diethylaluminium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; dichloromethane; butan-1-ol;
DOI:10.1021/jm00171a022

Reference yield:

: 128631-52-7
(+/-)-5-(benzyloxy)-3-(trimethylsiloxy)pentanenitrile

: 128631-54-9
(+/-)-1-<<2-amino-4-chloro-5-(2,2-diethoxyethyl)pyrimidin-6-yl>amino>-5-(benzyloxy)pentan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

2: 8.35 g / Et₃N / butan-1-ol / 72 h / 100 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; butan-1-ol;
DOI:10.1021/jm00171a022