5-(1,3-Dioxo-2,3-dihydro-1H-isoindole-2-ylmethyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole

Base Information

Chemical Name:5-(1,3-Dioxo-2,3-dihydro-1H-isoindole-2-ylmethyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole
CAS No.:199014-15-8
Molecular Formula:C₁₉H₁₆N₄O₃
Molecular Weight:348.361
Hs Code.:
DSSTox Substance ID:DTXSID501123890
Nikkaji Number:J1.087.663J

Synonyms:SCHEMBL7476683;DTXSID501123890;5-(1,3-Dioxo-2,3-dihydro-1H-isoindole-2-ylmethyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole;199014-15-8;2-[[1-[(4-Methoxyphenyl)methyl]-1H-1,2,4-triazol-5-yl]methyl]-1H-isoindole-1,3(2H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(1,3-Dioxo-2,3-dihydro-1H-isoindole-2-ylmethyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:348.12224039
Heavy Atom Count:26
Complexity:511

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CN2C(=NC=N2)CN3C(=O)C4=CC=CC=C4C3=O

Technology Process of 5-(1,3-Dioxo-2,3-dihydro-1H-isoindole-2-ylmethyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole

There total 5 articles about 5-(1,3-Dioxo-2,3-dihydro-1H-isoindole-2-ylmethyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 136918-14-4,85-41-6
phthalimide

: 199014-14-7
5-(hydroxymethyl)-1-(4-methoxybenzyl)-1,2,4-triazole

: 199014-15-8
5-(phthalimidomethyl)-1-(4-methoxybenzyl)-1,2,4-triazole

Guidance literature:: With di-isopropyl azodicarboxylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1080/00397919908085813

Reference yield: 91.0%

: 199014-14-7
5-(hydroxymethyl)-1-(4-methoxybenzyl)-1,2,4-triazole

: 199014-15-8
5-(phthalimidomethyl)-1-(4-methoxybenzyl)-1,2,4-triazole

Guidance literature:

Reference yield:

: 115201-42-8
1-(4-Methoxybenzyl)-1,2,4-triazole

: 199014-15-8
5-(phthalimidomethyl)-1-(4-methoxybenzyl)-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / 96 h / 130 °C

2: 91 percent / diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

With di-isopropyl azodicarboxylate; In tetrahydrofuran;
DOI:10.1080/00397919908085813