1α,25-dihydroxy-2-methylene-vitamin D₃

Base Information

Chemical Name:1α,25-dihydroxy-2-methylene-vitamin D₃
CAS No.:1428946-52-4
Molecular Formula:C₂₈H₄₄O₃
Molecular Weight:428.656
Hs Code.:

1α,25-dihydroxy-2-methylene-vitamin D<sub>3</sub>

Synonyms:1α,25-dihydroxy-2-methylene-vitamin D₃

Suppliers and Price of 1α,25-dihydroxy-2-methylene-vitamin D₃

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 1α,25-dihydroxy-2-methylene-vitamin D₃

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Technology Process of 1α,25-dihydroxy-2-methylene-vitamin D₃

There total 25 articles about 1α,25-dihydroxy-2-methylene-vitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1451070-70-4
1α-[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]vitamin D₃ tert-butyl dimethylsilyl ether

: 1428946-52-4
1α,25-dihydroxy-2-methylene-vitamin D₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1428946-46-6
(3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-2-methyl-4-methylene-cyclohex-1-enecarbaldehyde

: 1428946-52-4
1α,25-dihydroxy-2-methylene-vitamin D₃

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

2: copper(l) iodide; diethylamine; Pd(PPh₃)(OAc)2 / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

3: hydrogen / hexane; quinoline / 2.5 h / 20 °C

4: hexane / 14 h / Inert atmosphere; Heating

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; Pd(PPh₃)(OAc)2; tetrabutyl ammonium fluoride; hydrogen; diethylamine; In tetrahydrofuran; quinoline; hexane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.5b01295

Reference yield:

: (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-ethynyl-2-methyl-4-methylene-cyclohexene

: 1428946-52-4
1α,25-dihydroxy-2-methylene-vitamin D₃

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; diethylamine; Pd(PPh₃)(OAc)2 / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2: hydrogen / hexane; quinoline / 2.5 h / 20 °C

3: hexane / 14 h / Inert atmosphere; Heating

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

With copper(l) iodide; Pd(PPh₃)(OAc)2; tetrabutyl ammonium fluoride; hydrogen; diethylamine; In tetrahydrofuran; quinoline; hexane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.5b01295