cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

Base Information

Chemical Name:cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate
CAS No.:1402056-79-4
Molecular Formula:C₂₆H₂₅N₃O₆
Molecular Weight:475.501
Hs Code.:

cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

Synonyms:cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

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Chemical Property of cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

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Technology Process of cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

There total 7 articles about cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 2516-33-8
Cyclopropylmethanol

: 1402055-93-9
ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

: 1402056-79-4
cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

Guidance literature:: With oxo[hexa(trifluoroacetato)]tetrazinc; In N,N-dimethyl acetamide; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1402059-59-9
ethyl 2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

: 1402056-79-4
cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: L-proline / ethanol / 48 h / Reflux

2: oxo[hexa(trifluoroacetato)]tetrazinc / N,N-dimethyl acetamide / 0.5 h / 150 °C / Microwave irradiation

With oxo[hexa(trifluoroacetato)]tetrazinc; L-proline; In ethanol; N,N-dimethyl acetamide;

Reference yield:

: 103790-50-7
4-(2-hydroxyethoxy)-2-methylaniline

: 1402056-79-4
cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 16 h / 20 °C

2: L-proline / ethanol / 48 h / Reflux

3: oxo[hexa(trifluoroacetato)]tetrazinc / N,N-dimethyl acetamide / 0.5 h / 150 °C / Microwave irradiation

With oxo[hexa(trifluoroacetato)]tetrazinc; L-proline; In ethanol; N,N-dimethyl acetamide;