(1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

Base Information

Chemical Name:(1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester
CAS No.:872423-09-1
Molecular Formula:C₂₄H₂₄NO₃P
Molecular Weight:405.433
Hs Code.:

Synonyms:(1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

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Chemical Property of (1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

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Technology Process of (1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

There total 6 articles about (1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (1R,2R)-2-((R)-Amino-phenyl-methyl)-cyclopropanecarboxylic acid methyl ester; hydrochloride

: 1499-21-4
Diphenylphosphinic chloride

: 872423-09-1
(1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

Guidance literature:: (1R,2R)-2-((R)-Amino-phenyl-methyl)-cyclopropanecarboxylic acid methyl ester; hydrochloride; Diphenylphosphinic chloride; With triethylamine; In dichloromethane; at 100 ℃; for 0.166667h; microwave irradiation;

With MP-isocyanate; MP-trisamine; at 100 ℃; for 0.0833333h; microwave irradiation;
DOI:10.1016/j.tet.2005.09.016

Reference yield: 94.0%

: 850089-09-7
(1R,2R)-2-((R)-Amino-phenyl-methyl)-cyclopropanecarboxylic acid methyl ester

: 1499-21-4
Diphenylphosphinic chloride

: 872423-09-1
(1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/j.tet.2005.09.016

Reference yield:

: (1RS,2RS)-2-((RS)-1-amino-1-phenylmethyl)cyclopropane carboxylic acid methyl ester hydrochloride salt

: 872423-09-1
(1R,2R)-2-((R)-(diphenylphosphinylamino)phenyl-methyl)cyclopropane carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / ethanol; H₂O

2: 94 percent / CH₂Cl₂ / 10 h / 20 °C

With potassium carbonate; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2005.09.016