C₁₉H₂₉N₄O₃P

Base Information

• Chemical Name: C₁₉H₂₉N₄O₃P
• CAS No.: 1186139-60-5
• Molecular Formula: C₁₉H₂₉N₄O₃P
• Molecular Weight: 392.438
• Mol file: 1186139-60-5.mol

Synonyms:C₁₉H₂₉N₄O₃P

Chemical Property of C₁₉H₂₉N₄O₃P

Chemical Property:

Purity/Quality:

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Technology Process of C₁₉H₂₉N₄O₃P

There total 1 articles about C₁₉H₂₉N₄O₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-N,N'-bis(1'-methylethyl)-1,2-cyclohexanediamine (137944-38-8) → C19H29N4O3P (1186139-60-5)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: ammonia / dichloromethane / -78 °C / Inert atmosphere; Schlenk technique

3: titanium(IV) isopropylate / toluene / 12 h / 90 °C / Inert atmosphere; Schlenk technique

With titanium(IV) isopropylate; ammonia; triethylamine; phosphorus(V) oxybromide; In dichloromethane; toluene;

DOI:10.1002/asia.201901734

Reference yield: 90.0%

C19H29N4O3P (1186139-60-5) + isocyanoacetic acid methyl ester (39687-95-1) → methyl (4R,5S)-1-((3aR,7aR)-1,3-diisopropyl-2-oxidooctahydrobenzo[d][1,3,2]diazaphosphol-2-yl)-5-(4-nitrophenyl)-4,5-dihydro-1H-imidazole-4-carboxylate

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 16h; diastereoselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/acs.joc.6b03068

Reference yield: 85.0%

C19H29N4O3P (1186139-60-5) + benzylacrylate (2495-35-4,25036-21-9) → benzyl 2-((S)-(((3aR,7aR)-1,3-diisopropyl-2-oxidohexahydro-1H-benzo[d][1,3,2]diazaphosphol-2(3H)-yl)amino)(4-nitrophenyl)methyl)acrylate

Guidance literature:

With Dimethyl(phenyl)phosphine; In toluene; at 20 ℃; for 48h; diastereoselective reaction; Inert atmosphere;

DOI:10.1039/c6ob00847j

upstream raw materials:

(1R,2R)-N,N'-bis(1'-methylethyl)-1,2-cyclohexanediamine

Downstream raw materials:

C₃₆H₄₆N₅O₅P