Technology Process of 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetic acid
There total 9 articles about 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate;
With
methanol; sodium hydroxide;
In
dichloromethane;
at 20 ℃;
for 24h;
With
hydrogenchloride;
In
water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: boron trifluoride diethyl etherate / copper(l) chloride; acetic acid / tetrahydrofuran / 21 h / Reflux
2.1: nitric acid / water / 0 - 20 °C
2.2: pH 8 / Cooling with ice
3.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 96 h / 20 °C
4.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere
4.2: 1 h
5.1: dipyridinium dichromate / dichloromethane / 21 h / 20 °C / Molecular sieve
6.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 - 20 °C
7.1: sulfuric acid / 24 h / 0 - 20 °C / Reflux
8.1: perchloric acid / 48 h / 20 °C / Inert atmosphere
9.1: sodium hydroxide; methanol / dichloromethane / 24 h / 20 °C
9.2: pH 2
With
methanol; dipyridinium dichromate; perchloric acid; sulfuric acid; boron trifluoride diethyl etherate; nitric acid; diisobutylaluminium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; zinc(II) iodide;
acetic acid; copper(l) chloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: nitric acid / water / 0 - 20 °C
1.2: pH 8 / Cooling with ice
2.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 96 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere
3.2: 1 h
4.1: dipyridinium dichromate / dichloromethane / 21 h / 20 °C / Molecular sieve
5.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 - 20 °C
6.1: sulfuric acid / 24 h / 0 - 20 °C / Reflux
7.1: perchloric acid / 48 h / 20 °C / Inert atmosphere
8.1: sodium hydroxide; methanol / dichloromethane / 24 h / 20 °C
8.2: pH 2
With
methanol; dipyridinium dichromate; perchloric acid; sulfuric acid; nitric acid; diisobutylaluminium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; zinc(II) iodide;
In
1,4-dioxane; dichloromethane; water;