2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide

Base Information

• Chemical Name: 2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide
• CAS No.: 950179-48-3
• Molecular Formula: C₁₂H₁₄BrF₂NO₃
• Molecular Weight: 338.149
• Mol file: 950179-48-3.mol

Synonyms:2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide

Chemical Property of 2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide

There total 1 articles about 2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Ethyl bromodifluoroacetate (667-27-6) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide (950179-48-3)

Guidance literature:

With lanthanum(lll) triflate; In neat (no solvent); at 50 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1039/c6cc08535k

Reference yield: 69.0%

sorbic Acid (110-44-1,91751-55-2) + 2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide (950179-48-3) → 6-[2-(3,4-dimethoxy-phenyl)-ethylcarbamoyl]-6,6-didluoro-5-methyl-hex-3-enoic acid

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In water; acetonitrile; at 50 ℃; for 6h;

DOI:10.1016/j.jfluchem.2006.09.004

Reference yield:

2-bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,2-difluoro-acetamide (950179-48-3) + (E)-2,4-pentadienoic acid (21651-12-7) → (E)-6-[2-(3,4-dimethoxy-phenyl)-ethylcarbamoyl]-6,6-difluoro-hex-3-enoic acid + (Z)-6-[2-(3,4-dimethoxy-phenyl)-ethylcarbamoyl]-6,6-didluoro-hex-3-enoic acid

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In water; acetonitrile; at 50 ℃; for 6h; Title compound not separated from byproducts.;

DOI:10.1016/j.jfluchem.2006.09.004

upstream raw materials:

Ethyl bromodifluoroacetate

2-(3,4-dimethoxyphenyl)-ethylamine