(+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

Base Information

Chemical Name:(+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate
CAS No.:116078-72-9
Molecular Formula:C₂₄H₃₇ClN₂O₃
Molecular Weight:437.022
Hs Code.:

(+/-)-methyl α-<2-<bis(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

Synonyms:(+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

Chemical Property:

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Technology Process of (+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

There total 3 articles about (+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1440-60-4
1-chloroacetyl-piperidine

: 116078-69-4
(+/-)-methyl α-<2-ethyl>-2-chlorobenzeneacetate

: 116078-72-9
(+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; 1.) 0 deg C, 30 min, 2.) -50 deg C, 30 min, room temperature, 2 h;
DOI:10.1021/jm00119a017

Reference yield:

: 68284-62-8
(+/-)-α-<2-ethyl>-2-chlorophenylacetonitrile

: 116078-72-9
(+/-)-methyl α-<2-ethyl>-α-(2-chlorophenyl)-γ-oxo-1-piperidinebutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / conc. H₂SO₄ / 6 h / Heating

2: 37 percent / 1.) LDA / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) -50 deg C, 30 min, room temperature, 2 h

With sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jm00119a017