(3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

Base Information

Chemical Name:(3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide
CAS No.:109274-06-8
Molecular Formula:C₃₇H₄₃FN₂O₄
Molecular Weight:598.758
Hs Code.:

Synonyms:(3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

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Chemical Property of (3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

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Technology Process of (3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

There total 3 articles about (3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109273-99-6
(S)-6-{2-[3-(4-Fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxymethyl}-5,6-dihydro-pyran-2-one

: 100-46-9
benzylamine

: 109274-06-8
(3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

Guidance literature:: In benzene; at 50 ℃; for 12h;
DOI:10.1016/S0040-4039(00)85044-3

Reference yield:

: 108002-35-3
(4R,6S)-6-{2-[3-(4-Fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

: 109274-06-8
(3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Et₃N⁽¹⁺⁾SO₂N^(1-)COOCH₃ (Burgess reagent) / benzene / 1.5 h / 60 °C

2: 98 percent / benzene / 12 h / 50 °C

With Burgess Reagent; In benzene;
DOI:10.1016/S0040-4039(00)85044-3

Reference yield:

: 108025-19-0
(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxymethyl}-tetrahydro-pyran-2-one

: 109274-06-8
(3R,5S)-3-Benzylamino-6-{2-[3-(4-fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxy}-5-hydroxy-hexanoic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / tetrabutylammonium fluoride-trihydrate and p-toluenesulfonic acid-monohydrate / tetrahydrofuran / 12 h / 25 °C

2: 98 percent / benzene / 12 h / 50 °C

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(00)85044-3