4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

Base Information

Chemical Name:4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide
CAS No.:1015686-00-6
Molecular Formula:C₂₆H₃₁Cl₂N₅O₂
Molecular Weight:516.47
Hs Code.:

Synonyms:4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

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Chemical Property of 4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

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Technology Process of 4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

There total 5 articles about 4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917918-15-1
rac-3-bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

: 1015686-00-6
4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

Guidance literature:: (3S)-[(4-methyl-piperazine-1-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; for 0.5h;

rac-3-bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; for 1h;

Reference yield:

: 56341-37-8
6-chloro-2-oxindole

: 1015686-00-6
4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyrrolidine / methanol / 3 h / 70 °C

2.1: sodium tetrahydroborate / methanol; dimethyl sulfoxide / 0.5 - 1 h / 20 °C

3.1: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 4 h / 20 °C

4.1: trifluoroacetic acid / 0.5 h

4.2: 1 h

With pyrrolidine; sodium tetrahydroborate; pyridinium hydrobromide perbromide; trifluoroacetic acid; In methanol; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 917917-78-3
rac-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

: 1015686-00-6
4-methyl-piperazine-1-carboxylic acid rac-{1-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperidin-(3S)-yl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 4 h / 20 °C

2.1: trifluoroacetic acid / 0.5 h

2.2: 1 h

With pyridinium hydrobromide perbromide; trifluoroacetic acid; In water; tert-butyl alcohol;