15-S-benzylcatharanthine

Base Information

• Chemical Name: 15-S-benzylcatharanthine
• CAS No.: 103027-18-5
• Molecular Formula: C₂₈H₃₀N₂O₂S
• Molecular Weight: 458.624
• Mol file: 103027-18-5.mol

Synonyms:15-S-benzylcatharanthine

Chemical Property of 15-S-benzylcatharanthine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 15-S-benzylcatharanthine

There total 3 articles about 15-S-benzylcatharanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

15-oxocoronaridine (63944-55-8,63976-18-1,103129-30-2,103129-31-3) + phenylmethanethiol (100-53-8) → 15-S-benzylcatharanthine (103027-18-5)

Guidance literature:

With boron trifluoride diethyl etherate; In acetic acid; at 22 ℃; for 24h;

DOI:10.1021/jo00365a012

Reference yield:

15-((tert-butyldimethylsilyl)oxy)catharanthine (103027-14-1) → 15-S-benzylcatharanthine (103027-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammonium fluoride / tetrahydrofuran / a) -78 deg C, 10 min, b) 20 deg C, 20 min

2: 100 percent / SiO₂

3: 70 percent / boron trifluoride etherate / acetic acid / 24 h / 22 °C

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; silica gel; In tetrahydrofuran; acetic acid;

DOI:10.1021/jo00365a012

Reference yield:

20-epi-15-oxocoronaridine (63944-55-8,63976-18-1,103129-30-2,103129-31-3) → 15-S-benzylcatharanthine (103027-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SiO₂

2: 70 percent / boron trifluoride etherate / acetic acid / 24 h / 22 °C

With boron trifluoride diethyl etherate; silica gel; In acetic acid;

DOI:10.1021/jo00365a012

upstream raw materials:

15-oxocoronaridine

phenylmethanethiol

15-((tert-butyldimethylsilyl)oxy)catharanthine

20-epi-15-oxocoronaridine