6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride

Base Information

• Chemical Name: 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride
• CAS No.: 139331-59-2
• Molecular Formula: C₂₂H₂₄FN₃O₃S*2ClH
• Molecular Weight: 502.437
• Mol file: 139331-59-2.mol

Synonyms:6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride

Chemical Property of 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride

There total 6 articles about 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

6-(3-bromopropyl)-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one (139331-40-1) + 1-(4-Fluorophenyl)piperazine (2252-63-3) → 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride (139331-59-2)

Guidance literature:

In ethyl acetate; at 110 ℃;

DOI:10.1248/cpb.39.2888

Reference yield:

[1,3]dioxolo[4’,5’:4,5]benzo[1,2-d]thiazol-6-amine (50850-94-7) → 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride (139331-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / 2-methoxy-ethanol; H₂O / Heating

2: 45 percent / dimethylformamide / Ambient temperature

3: 80.6 percent / ethyl acetate / 110 °C

With potassium hydroxide; In 2-methoxy-ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.2888

Reference yield:

1-(benzo[d][1,3]dioxol-5-yl)thiourea (65069-55-8) → 6-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one.dihydrochloride (139331-59-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) bromine, AcOH 2.) 25percent NH₄OH / 1.) room temp. 2.) room temp.

2: KOH / 2-methoxy-ethanol; H₂O / Heating

3: 45 percent / dimethylformamide / Ambient temperature

4: 80.6 percent / ethyl acetate / 110 °C

With potassium hydroxide; ammonium hydroxide; bromine; acetic acid; In 2-methoxy-ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.2888

upstream raw materials:

6-(3-bromopropyl)-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one

1-(4-Fluorophenyl)piperazine

methyl 2,5-dibromovalerate

[1,3]dioxolo[4’,5’:4,5]benzo[1,2-d]thiazol-6-amine