Technology Process of Benzeneethanamine, beta-(fluoromethylene)-3,4-dimethoxy-, hydrochloride, (betaE)-
There total 7 articles about Benzeneethanamine, beta-(fluoromethylene)-3,4-dimethoxy-, hydrochloride, (betaE)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) LDA / 1.) THF, -78 deg C, 1h, 2.) THF, overnight
2: 1.) sodium tert-butoxide / 1.) THF, 15 min, 2.) THF, 30 min
3: trifluoroacetic acid / 1 h / Ambient temperature
4: 2M aq. NaOH / tetrahydrofuran / 0.25 h / Ambient temperature
5: 74 percent / 1M Dibal / hexane; CH2Cl2 / 1 h / Ambient temperature
6: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran
7: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min
With
hydrogenchloride; sodium hydroxide; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid; sodium t-butanolate; lithium diisopropyl amide; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00380a007
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran
2: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min
With
hydrogenchloride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1021/jm00380a007
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium tert-butoxide / 1.) THF, 15 min, 2.) THF, 30 min
2: trifluoroacetic acid / 1 h / Ambient temperature
3: 2M aq. NaOH / tetrahydrofuran / 0.25 h / Ambient temperature
4: 74 percent / 1M Dibal / hexane; CH2Cl2 / 1 h / Ambient temperature
5: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran
6: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min
With
hydrogenchloride; sodium hydroxide; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid; sodium t-butanolate; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00380a007
