methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Base Information

Chemical Name:methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate
CAS No.:937054-13-2
Molecular Formula:C₂₃H₂₂ClNO₅
Molecular Weight:427.884
Hs Code.:

Synonyms:methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

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Chemical Property of methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

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Technology Process of methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

There total 5 articles about methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 937057-52-8
methyl (E)-3-(1-{4-chloro-2-[(2,3-dimethoxyphenyl)(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

: 937054-13-2
methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937054-13-2
methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 7 h / 100 °C

2: sodium tetrahydroborate / methanol / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; In methanol; dichloromethane; toluene; 1: Wittig reaction / 3: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937054-13-2
methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 20 °C / Cooling with ice

1.2: 3 h / 50 °C

2.1: toluene / 7 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; toluene; 1.1: Vilsmeier reaction / 1.2: Vilsmeier reaction / 2.1: Wittig reaction / 4.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054