8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Base Information

Chemical Name:8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione
CAS No.:1351803-68-3
Molecular Formula:C₁₉H₂₅N₃O₅
Molecular Weight:375.425
Hs Code.:

Synonyms:8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

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Chemical Property of 8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

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Technology Process of 8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

There total 10 articles about 8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1229022-24-5
4-hydroxy-8-methoxy-1-methyl-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 1351803-68-3
8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: With nitric acid; In chloroform; at -5 - 20 ℃; for 72.5h;

Reference yield:

: 1145784-38-8
4-hydroxy-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 1351803-68-3
8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 1 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / water; methanol / 22 h / 36 °C / 3000.3 Torr

4.1: nitric acid / chloroform / 72.5 h / -5 - 20 °C

With hydrogen; nitric acid; potassium carbonate; lithium hexamethyldisilazane; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; chloroform; water; acetone;

Reference yield:

: 52629-46-6
(2,4,6-trimethyl-phenyl)acetyl chloride

: 1351803-68-3
8-methoxy-1-methyl-3-nitro-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / tetrahydrofuran / 4.5 h / 0 - 20 °C

2.1: sulfuric acid / 2.25 h / 15 - 20 °C

2.2: pH 5 - 5.5 / Cooling with ice

3.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

3.2: pH 5 - 6 / Cooling with ice

4.1: nitric acid / chloroform / 72.5 h / -5 - 20 °C

With sulfuric acid; nitric acid; sodium methylate; triethylamine; dmap; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;