methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Base Information

Chemical Name:methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate
CAS No.:1313358-22-3
Molecular Formula:C₄₀H₅₂N₆O₇
Molecular Weight:728.889
Hs Code.:

methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Synonyms:methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

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Chemical Property of methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

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Technology Process of methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

There total 6 articles about methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313358-76-7
(1S,3R)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxylic acid

: 198904-87-9
(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride

: 1313358-22-3
methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Guidance literature:: (1S,3R)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 ℃;

(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 288848-24-8
(1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid

: 1313358-22-3
methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.1: sodium azide; methanesulfonic acid / 1,2-dimethoxyethane / 48 h / -45 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

4.1: hydrogenchloride; water / 2 h / Reflux

4.2: 16 h / 0 - 20 °C / pH 8 - 9

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 °C

5.2: 16 h / 20 °C

With hydrogenchloride; sodium azide; methanesulfonic acid; water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium 10% on activated carbon; In 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; 2.1: Schmidt Reaction;

Reference yield:

: 80-57-9,1196-01-6
(-)-Verbenone

: 1313358-22-3
methyl (1R,3S)-3-((2S,3S)-4-(2-((1S,3R)-3-methoxycarbonylamino-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: sodium azide; methanesulfonic acid / 1,2-dimethoxyethane / 48 h / -45 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

5.1: hydrogenchloride; water / 2 h / Reflux

5.2: 16 h / 0 - 20 °C / pH 8 - 9

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 °C

6.2: 16 h / 20 °C

With hydrogenchloride; sodium periodate; sodium azide; methanesulfonic acid; water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrachloromethane; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3.1: Schmidt Reaction;