(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

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Chemical Name:(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid
CAS No.:327184-53-2
Molecular Formula:C₃₃H₂₉N₃O₁₀
Molecular Weight:627.607
Hs Code.:

(4-{4-(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-6-[(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-<i>d</i>][1,3]dioxol-2-yl}-phenoxy)-acetic acid

Synonyms:(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

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Chemical Property of (4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

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Technology Process of (4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

There total 7 articles about (4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 327184-52-1
(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid methyl ester

: 327184-53-2
(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00560-6

Reference yield:

: 362-43-6
2',3'-O-isopropylideneuridine

: 327184-53-2
(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / DMAP

2: 88 percent / NaN₃ / dimethylformamide / 70 °C

3: H₂ / 10 percent Pd/C / methanol; acetic acid / 760 Torr

4: 10 percent aq. Na₂CO₃ / dioxane

5: 95 percent / aq. TFA

6: 89 percent / pTsOH; (EtO)3CH / dimethylformamide / 20 °C

7: 59 percent / 3 percent aq. Na₂CO₃ / dioxane / 20 °C

With dmap; sodium azide; hydrogen; sodium carbonate; toluene-4-sulfonic acid; orthoformic acid triethyl ester; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00560-6

Reference yield:

: 15083-05-3
5'-azido-5'-deoxy-2',3'-O-isopropylideneuridine

: 327184-53-2
(4-{4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-tetrahydro-furo[3,4-d][1,3]dioxol-2-yl}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10 percent Pd/C / methanol; acetic acid / 760 Torr

2: 10 percent aq. Na₂CO₃ / dioxane

3: 95 percent / aq. TFA

4: 89 percent / pTsOH; (EtO)3CH / dimethylformamide / 20 °C

5: 59 percent / 3 percent aq. Na₂CO₃ / dioxane / 20 °C

With hydrogen; sodium carbonate; toluene-4-sulfonic acid; orthoformic acid triethyl ester; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00560-6