(S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

Base Information

Chemical Name:(S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid
CAS No.:1425708-12-8
Molecular Formula:C₃₂H₄₅NO₁₀S
Molecular Weight:635.776
Hs Code.:

Synonyms:(S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

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Chemical Property of (S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

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Technology Process of (S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

There total 7 articles about (S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1425708-10-6
(S)-(+)-6-(4-(2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl)phenyl)hexanoic acid methyl ester

: 1425708-12-8
(S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

Guidance literature:: With Novozym 435; In aq. phosphate buffer; dichloromethane; acetone; at 50 ℃; for 52h; Inert atmosphere; Enzymatic reaction;
DOI:10.1002/chem.201202474

Reference yield:

: 18938-60-8
(S)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate

: 1425708-12-8
(S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 50 °C / Inert atmosphere

1.2: 48 h / Inert atmosphere

2.1: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C / Inert atmosphere

3.1: Novozym 435 / dichloromethane; aq. phosphate buffer; acetone / 52 h / 50 °C / Inert atmosphere; Enzymatic reaction

With dmap; Novozym 435; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; triethylamine; In aq. phosphate buffer; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/chem.201202474

Reference yield:

: 1214908-96-9
(S)-(+)-2-tert-butoxycarbonylamino-3-[4-(2-hydroxyethoxy)phenyl]propionic acid tert-butyl ester

: 1425708-12-8
(S)-(+)-6-(4-[2-[4-(2-tert-butoxycarbonyl-2-tert-butoxycarbonylaminoethyl)phenoxy]ethoxysulfonyl]phenyl)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C / Inert atmosphere

2: Novozym 435 / dichloromethane; aq. phosphate buffer; acetone / 52 h / 50 °C / Inert atmosphere; Enzymatic reaction

With dmap; Novozym 435; triethylamine; In aq. phosphate buffer; dichloromethane; acetone;
DOI:10.1002/chem.201202474