3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

Base Information

Chemical Name:3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane
CAS No.:937030-48-3
Molecular Formula:C₂₅H₃₀F₂N₂O₃
Molecular Weight:444.522
Hs Code.:

Synonyms:3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

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Chemical Property of 3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

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Technology Process of 3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

There total 1 articles about 3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 869494-16-6
3,6-diazabicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester

: 321365-84-8
2-[bis(4-fluorophenyl)methoxy]ethyl iodide

: 937030-48-3
3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

Guidance literature:: With potassium carbonate; In various solvent(s); at 115 ℃; for 17h;
DOI:10.1016/j.bmc.2007.03.035

Reference yield:

: 937030-48-3
3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

: 937030-59-6
(3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-3,6-diazabicyclo[3.1.1]heptan-6-yl)(1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / formic acid / 4.5 h / 20 °C

2: 85 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide / CH₂Cl₂ / 20 h / 20 °C

With formic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2007.03.035

Reference yield:

: 937030-48-3
3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-tert-butyloxycarbonyl-3,6-diazabicyclo[3.1.1]heptane

: 937030-60-9
(benzo[b]thiophen-2-yl)(3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-3,6-diazabicyclo[3.1.1]heptan-6-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / formic acid / 4.5 h / 20 °C

2: 51 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide / CH₂Cl₂ / 20 h / 20 °C

With formic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2007.03.035