C₂₁H₁₈NOP

Base Information

• Chemical Name: C₂₁H₁₈NOP
• CAS No.: 154051-02-2
• Molecular Formula: C₂₁H₁₈NOP
• Molecular Weight: 331.354
• Mol file: 154051-02-2.mol

Synonyms:C₂₁H₁₈NOP

Chemical Property of C₂₁H₁₈NOP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₈NOP

There total 2 articles about C₂₁H₁₈NOP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indan-1-one oxime (68253-35-0,100485-57-2,3349-60-8) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → C21H18NOP (154051-02-2)

Guidance literature:

With triethylamine; In dichloromethane; Petroleum ether; at -45 - -40 ℃;

DOI:10.1021/jo062006y

Reference yield:

inden-1-one (83-33-0) → C21H18NOP (154051-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl; NaOAc / ethanol; H₂O / Heating

2: triethylamine / petroleum ether; CH₂Cl₂ / -45 - -40 °C

With hydroxylamine hydrochloride; sodium acetate; triethylamine; In ethanol; dichloromethane; water; Petroleum ether;

DOI:10.1021/jo062006y

Reference yield: 95.0%

C21H18NOP (154051-02-2) → (R)-N-(1-indanyl)-P,P-diphenylphosphinic amide

Guidance literature:

With (S,S)-N,N'-bis[o-(diphenylphosphino)benzylidene]-1,2-diaminocyclohexane; [NEt₃H][HFe₃(CO)₁₁]; potassium hydroxide; In isopropyl alcohol; at 20 - 45 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201002456

upstream raw materials:

indan-1-one oxime

chloro-diphenylphosphine

inden-1-one

Downstream raw materials:

(S)-(-)-N-(1-indanamine)diphenylphosphinamide

Refernces

• 1、 Das, Braja Gopal,Nallagonda, Rajender,Dey, Dhananjay,Ghorai, Prasanta. "Synthesis of Air- and Moisture-Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction". supporting information. p. 12601 - 12605. Retrieved 2015/09/01.
• 2、 Nolin, Kristine A.,Ahn, Richard W.,Kobayashi, Yusuke,Kennedy-Smith, Joshua J.,Toste, F. Dean. "Enantioselective reduction of ketones and imines catalyzed by (CN-Box)ReV-oxo complexes". supporting information; experimental part. p. 9555 - 9562. Retrieved 2010/10/03.