1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

Base Information

Chemical Name:1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole
CAS No.:1310530-33-6
Molecular Formula:C₂₈H₂₈N₆O
Molecular Weight:464.57
Hs Code.:

Synonyms:1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

There total 5 articles about 1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1310531-85-1
1-tert-butyl-2-(5-methoxy-2-pyrazol-1-ylphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

: 115170-40-6
7-aza-5-bromoindoline

: 1310530-33-6
1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

Guidance literature:: With potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In water; toluene; at 100 ℃; for 4h; Microwave irradiation; Sealed;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310530-33-6
1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 16 h / 60 °C

2: zinc; ammonium formate / water; methanol / 2 h / 70 °C

3: Oxone / N,N-dimethyl-formamide; water / 3 h / 20 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; propan-1-ol / 48 h / 90 °C / Inert atmosphere

5: potassium carbonate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 4 h / 100 °C / Microwave irradiation; Sealed

With Oxone; ammonium formate; potassium acetate; potassium carbonate; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; methanol; propan-1-ol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310530-33-6
1-tert-butyl-5-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(5-methoxy-2-pyrazol-1-ylphenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; ammonium formate / water; methanol / 2 h / 70 °C

2: Oxone / N,N-dimethyl-formamide; water / 3 h / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; propan-1-ol / 48 h / 90 °C / Inert atmosphere

4: potassium carbonate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 4 h / 100 °C / Microwave irradiation; Sealed

With Oxone; ammonium formate; potassium acetate; potassium carbonate; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In methanol; propan-1-ol; water; N,N-dimethyl-formamide; toluene;