(S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester
CAS No.:217446-25-8
Molecular Formula:C₁₈H₁₅NO₄
Molecular Weight:309.321
Hs Code.:

Synonyms:(S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

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Chemical Property of (S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

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Technology Process of (S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

There total 4 articles about (S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 2198-64-3,1205-02-3,90988-29-7
N-Benzoylalanine

: 217446-25-8
(S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

Guidance literature:: With (R)-7-benzyloxy-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole; N-ethyl-N,N-diisopropylamine; In toluene; at -55 ℃; for 10h; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/d0sc00808g

Reference yield:

: 886466-27-9
4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 217446-25-8
(S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

: (R)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

: rac-2-benzoylamino-2-methylmalonic acid benzyl ester (2-methoxyethyl) ester

: (R)-2-benzoylamino-2-methylmalonic acid benzyl ester (2-methoxyethyl) ester

Guidance literature:: With copper diacetate; (S)-DTBM-SEGPHOS; In toluene; at 20 ℃; for 49h; Title compound not separated from byproducts;
DOI:10.1021/ja058112j

Reference yield:

: 886466-68-8
5-benzyloxycarbonyloxy-4-methyl-2-phenyloxazole

: 217446-25-8
(S)-4-methyl-5-oxo-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

Guidance literature:: With (R)-7-benzyloxy-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole; In toluene; at 20 ℃; for 144h; optical yield given as %ee; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja109069k