3,6-Diisobutylhexahydropyrazine-2,5-dione

Base Information

Chemical Name:3,6-Diisobutylhexahydropyrazine-2,5-dione
CAS No.:1436-27-7
Molecular Formula:C₁₂H₂₂N₂O₂
Molecular Weight:226.319
Hs Code.:
Mol file:1436-27-7.mol

Synonyms:2,5-Piperazinedione,3,6-diisobutyl- (6CI,7CI,8CI); 3,6-Diisobutyl-2,5-piperazinedione;Cyclo(leucylleucyl); Leucine, bimol. cyclic peptide; Leucinimide; NSC 241085

Suppliers and Price of 3,6-Diisobutylhexahydropyrazine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Cyclo(Leu-Leu)
10mg
$ 332.00

Total 12 raw suppliers

Chemical Property of 3,6-Diisobutylhexahydropyrazine-2,5-dione

Chemical Property:

Vapor Pressure:4.01E-08mmHg at 25°C
Melting Point:270 - 272 °C
Boiling Point:445.2°C at 760 mmHg
Flash Point:177.9°C
PSA：58.20000
Density:0.969g/cm³
LogP:1.71940

Purity/Quality:

99% ^*data from raw suppliers

Cyclo(Leu-Leu) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,6-Diisobutylhexahydropyrazine-2,5-dione

There total 42 articles about 3,6-Diisobutylhexahydropyrazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 952-43-2,952-45-4,16679-66-6,16679-67-7,63729-97-5,1436-27-7
3,6-diisobutyl-2,5-piperazinedione

Guidance literature:: In N,N-dimethyl-formamide; at 200 ℃; for 0.333333h; under 12901.3 Torr; Microwave irradiation;
DOI:10.1039/c1gc15043j

Reference yield: 90.0%

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 952-43-2,952-45-4,1436-27-7,16679-66-6,16679-67-7,63729-97-5
(3S,6S)-3,6-diisobutylpiperazine-2,5-dione

Guidance literature:: N-tert-butoxycarbonyl-L-leucine; With dmap; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

With trifluoroacetic acid; In dichloromethane; for 0.5h;

N-tert-butoxycarbonyl-L-leucine; Further stages;
DOI:10.1016/j.tet.2015.08.051