1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one

Base Information

• Chemical Name: 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one
• CAS No.: 1261287-89-1
• Molecular Formula: C₂₂H₂₀O
• Molecular Weight: 300.4
• Mol file: 1261287-89-1.mol

Synonyms:1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one

Chemical Property of 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one

There total 4 articles about 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-1-([1,1'-biphenyl]-4-yl)-N-(4-methoxyphenyl)ethan-1-imine + styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one (1261287-89-1)

Guidance literature:

(E)-1-([1,1'-biphenyl]-4-yl)-N-(4-methoxyphenyl)ethan-1-imine; With cobalt(II) bromide; cyclohexylmagnesium bromide; P(p-C₆H₄F)3; In tetrahydrofuran; for 0.5h; Schlenk technique; Inert atmosphere; Cooling with ice;

styrene; In tetrahydrofuran; at 20 ℃; for 24h; regioselective reaction; Schlenk technique; Inert atmosphere; Cooling with ice;

DOI:10.1246/cl.130508

Reference yield:

(E)-1-([1,1'-biphenyl]-4-yl)-N-(4-methoxyphenyl)ethan-1-imine + styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one (1261287-89-1) + 1-(3-phenethyl-[1,1'-biphenyl]-4-yl)ethanone (1261287-90-4)

Guidance literature:

(E)-1-([1,1'-biphenyl]-4-yl)-N-(4-methoxyphenyl)ethan-1-imine; With neopentylmagnesium bromide; 1,3-bis(mesityl)imidazolium chloride; cobalt(II) bromide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

styrene; In tetrahydrofuran; at 60 ℃; for 72h; Inert atmosphere;

With hydrogenchloride; water; regioselective reaction;

DOI:10.1021/ja108809u

Reference yield:

C29H27NO → 1-(3-(1-phenylethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one (1261287-89-1)

Guidance literature:

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201600403

upstream raw materials:

styrene

biphenyl-4-acetaldehyde