D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester

Base Information

• Chemical Name: D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester
• CAS No.: 857081-53-9
• Molecular Formula: C₂₉H₃₀BrNO₇S
• Molecular Weight: 616.53

Synonyms:D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester

Chemical Property of D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester

Chemical Property:

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Technology Process of D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester

There total 5 articles about D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

5-bromo-2-chloromethyl-4-methoxy-3-methylbenzofuran (857081-52-8) + methyl N-[(4'-hydroxy-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate (854372-30-8) → D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester (857081-53-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2005.07.076

Reference yield:

methyl N-[(4-bromophenyl)sulfonyl]-D-valinate (544709-92-4) → D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester (857081-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 8 h / 90 °C

2: 40 percent / K₂CO₃ / dimethylformamide / 12 h / 20 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmc.2005.07.076

Reference yield:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → D-2-[4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methyl butyric acid methyl ester (857081-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 8 h / 90 °C

2: 40 percent / K₂CO₃ / dimethylformamide / 12 h / 20 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmc.2005.07.076

upstream raw materials:

5-bromo-2-chloromethyl-4-methoxy-3-methylbenzofuran

methyl N-[(4'-hydroxy-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

5-bromo-4-methoxy-3-methyl-benzofuran-2-carboxylic acid

(5-bromo-4-methoxy-3-methylbenzofuran-2-yl)methanol

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