2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-1,3,3(4H)-naphthalenetricarbonitrile

Base Information

Chemical Name:2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-1,3,3(4H)-naphthalenetricarbonitrile
CAS No.:77198-44-8
Molecular Formula:C₁₉H₁₅FN₄
Molecular Weight:318.353
Hs Code.:

Synonyms:2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-1,3,3(4H)-naphthalenetricarbonitrile

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Technology Process of 2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-1,3,3(4H)-naphthalenetricarbonitrile

There total 4 articles about 2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-1,3,3(4H)-naphthalenetricarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 459-57-4
4-fluorobenzaldehyde

: 109-77-3
malononitrile

: 77198-44-8
2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

Guidance literature:: With triethylammonium acetate; In neat (no solvent); at 80 ℃; for 4h; Reagent/catalyst; Green chemistry;
DOI:10.1080/00304948.2017.1384282

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 77198-44-8
2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine / ethanol / 20 °C

2: ethanol / 20 °C

With morpholine; In ethanol; 1: |Michael Addition;
DOI:10.1002/jhet.3742

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 77198-44-8
2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine / ethanol / 20 °C

2: ethanol / 20 °C

With morpholine; In ethanol; 1: |Michael Addition;
DOI:10.1002/jhet.3742