3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

Base Information

Chemical Name:3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide
CAS No.:910865-32-6
Molecular Formula:C₁₈H₂₈N₂O₃S
Molecular Weight:352.498
Hs Code.:

Synonyms:3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

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Chemical Property of 3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

Chemical Property:

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Technology Process of 3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

There total 8 articles about 3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 627539-06-4
tert-butyl 4-methyl-4-nitropentanoate

: 910865-32-6
3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 60 percent / H₂ / Raney nickiel / ethanol

2.1: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

3.1: 69 percent / SOCl₂ / 48 h / 40 °C

4.1: 82 percent / KOH; H₂O / methanol / 20 °C

5.1: CDI; HOBt / tetrahydrofuran / 20 °C

5.2: 155 mg / NH₃ / tetrahydrofuran; H₂O / 20 °C

With potassium hydroxide; thionyl chloride; water; hydrogen; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; Raney nickiel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1039/b606882k

Reference yield:

: C₁₈H₁₉N₃O₃S

: 910865-32-6
3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

2.1: 69 percent / SOCl₂ / 48 h / 40 °C

3.1: 82 percent / KOH; H₂O / methanol / 20 °C

4.1: CDI; HOBt / tetrahydrofuran / 20 °C

4.2: 155 mg / NH₃ / tetrahydrofuran; H₂O / 20 °C

With potassium hydroxide; thionyl chloride; water; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol;
DOI:10.1039/b606882k

Reference yield:

: 910865-10-0
3-hydroxy-4-methyl-4-(phenylthio)pentanoic acid

: 910865-32-6
3-hydroxy-4-methyl-4-phenylsulfanyl-(3'-carbomyl-1',1'-dimethyl-propyl)-pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: DCC / tetrahydrofuran / 20 °C

2.1: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

3.1: 69 percent / SOCl₂ / 48 h / 40 °C

4.1: 82 percent / KOH; H₂O / methanol / 20 °C

5.1: CDI; HOBt / tetrahydrofuran / 20 °C

5.2: 155 mg / NH₃ / tetrahydrofuran; H₂O / 20 °C

With potassium hydroxide; thionyl chloride; water; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol;
DOI:10.1039/b606882k