N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

Base Information

Chemical Name:N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide
CAS No.:1400708-23-7
Molecular Formula:C₂₃H₂₅ClN₆O
Molecular Weight:436.944
Hs Code.:

Synonyms:N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

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Chemical Property of N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

Chemical Property:

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Technology Process of N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

There total 6 articles about N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400707-02-9
[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropylamine

: 101184-11-6
4-(2-methyl-1H-imidazol-1-yl)benzoic acid

: 1400708-23-7
N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 1400708-23-7
N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C / Microwave irradiation

2: sodium hydroxide; water / methanol / 1 h / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1400708-23-7
N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide; 1,4-dioxane / 16 h / 120 °C / glass pressure reaction vessel

2.1: hydrogenchloride / 60 h / 20 °C

2.2: pH ~ 14 / Cooling with ice

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C / Inert atmosphere

3.3: pH ~ 14 / Cooling with ice

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;