(2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester

Base Information

• Chemical Name: (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester
• CAS No.: 857638-22-3
• Molecular Formula: C₁₇H₂₅NO₅S
• Molecular Weight: 355.455
• Mol file: 857638-22-3.mol

Synonyms:(2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester

Chemical Property of (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester

There total 3 articles about (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

(2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid (857638-18-7) + diazomethyl-trimethyl-silane (18107-18-1) → (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester (857638-22-3)

Guidance literature:

In methanol; diethyl ether; at 20 ℃;

DOI:10.1039/b416349d

Reference yield:

2,4,6-trimethoxybenzaldehyde (830-79-5) + (2R)-3-allylsulfanyl-2-amino-propionic acid methyl ester (328975-04-8) → (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester (857638-22-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/b416349d

Reference yield:

S-allyl cysteine (21593-77-1,49621-03-6) → (2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid methyl ester (857638-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; methanol; CH₂Cl₂ / 2 h / 20 °C

2: 697 mg / NaBH(OAc)3 / CH₂Cl₂ / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; In methanol; diethyl ether; dichloromethane;

DOI:10.1039/b416349d

upstream raw materials:

(2R)-3-allylsulfanyl-2-(2,4,6-trimethoxybenzylamino)-propionic acid

diazomethyl-trimethyl-silane

2,4,6-trimethoxybenzaldehyde

(2R)-3-allylsulfanyl-2-amino-propionic acid methyl ester

Downstream raw materials:

(2R,2'S)-3-allylsulfanyl-2-[[2'-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4'-enoyl]-(2,4,6-trimethoxybenzyl)-amino]-propionic acid methyl ester