[(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester

Base Information

• Chemical Name: [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester
• CAS No.: 1054640-89-9
• Molecular Formula: C₃₁H₄₉N₃O₄S
• Molecular Weight: 559.814

Synonyms:[(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester

Chemical Property of [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester

There total 16 articles about [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentane-cis-1,2-dicarboxylic acid anhydride (35878-28-5,743438-34-8) → [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester (1054640-89-9)

Guidance literature:

Multi-step reaction with 10 steps

1: 3 h / Heating

3: 23 g / oxalyl chloride / toluene / 28 h

4: 20 g / H₂, 2,6-lutidine / 10percent Pd/C / tetrahydrofuran / 18 h / 2585.7 Torr

5: 1.) lithium bis(trimethylsilyl)amide, 3.) AcOH

6: 12 g / H₂ / 5percent Pd/C / tetrahydrofuran / 2585.7 Torr

7: 68 percent / BH₃*Me₂S / tetrahydrofuran / 3 h / 25 °C

8: trimethylaluminum / tetrahydrofuran; toluene / 24 h / 25 °C

9: 39 percent / propan-2-ol / 80 °C

10: H₂, Et₃N / 10percent Pd/BaSO₄ / tetrahydrofuran / 48 h

With 2,6-dimethylpyridine; oxalyl dichloride; dimethylsulfide borane complex; hydrogen; trimethylaluminum; acetic acid; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; Pd-BaSO₄; In tetrahydrofuran; isopropyl alcohol; toluene;

DOI:10.1021/jm00034a016

Reference yield:

(3R,4S)-3-Methoxymethoxy-5-methyl-hexane-1,4-diol (147949-38-0) → [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester (1054640-89-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 3.6 g / Et₃N / CH₂Cl₂ / 12 h / -40 - 24 °C

2: 50 percent / Li₂S / dimethylformamide / 6 h / 60 °C

3: 96 percent / thiophenol, BF₃*OEt₂ / CH₂Cl₂ / 1.5 h / 0 - 24 °C

4: 91 percent / Et₃N / CH₂Cl₂ / 12 h / 24 °C

5: H₂, Et₃N / 10percent Pd/BaSO₄ / tetrahydrofuran / 48 h

With lithium sulfide; boron trifluoride diethyl etherate; hydrogen; thiophenol; triethylamine; Pd-BaSO₄; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00034a016

Reference yield:

3(R)-<(methoxymethyl)oxy>-2(R)-(1-methylethyl)tetrahydrothiophene (147949-24-4) → [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester (1054640-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / thiophenol, BF₃*OEt₂ / CH₂Cl₂ / 1.5 h / 0 - 24 °C

2: 91 percent / Et₃N / CH₂Cl₂ / 12 h / 24 °C

3: H₂, Et₃N / 10percent Pd/BaSO₄ / tetrahydrofuran / 48 h

With boron trifluoride diethyl etherate; hydrogen; thiophenol; triethylamine; Pd-BaSO₄; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00034a016

upstream raw materials:

Carbonic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester pyridin-2-yl ester

N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-azidobutyl>octahydro-(3S,4aS,7aS)-1H-pyrindene-3(S)-carboxamide

cyclopentane-cis-1,2-dicarboxylic acid anhydride

(3R,4S)-3-Methoxymethoxy-5-methyl-hexane-1,4-diol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1054640-89-9 [(1S,2R)-1-Benzyl-3-((3S,4aS,7aS)-3-tert-butylcarbamoyl-octahydro-[2]pyrindin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send