Bis-PEG13-PFP ester

Base Information

• Chemical Name: Bis-PEG13-PFP ester
• CAS No.: 1383567-59-6
• Molecular Formula: C₄₂H₅₆F₁₀O₁₇
• Molecular Weight: 1022.88
• Mol file: 1383567-59-6.mol

Synonyms:PfpOOC-CH₂CH₂O(CH₂CH₂O)12CH₂CH₂-COOPfp

Chemical Property of Bis-PEG13-PFP ester

Chemical Property:

• Boiling Point: 817.3±65.0 °C(Predicted)
• Density: 1.312±0.06 g/cm3(Predicted)
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis-PEG13-PFPester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bis-PEG13-PFP ester is a PEG linker with two activated PFP ester moieties. PFP esters can react with amine groups to form amide bonds. They are also less susceptible to undergo hydrolysis compared to other amine reactive groups. The hydrophilic PEG linker increase the water solubility of the compond in aqueous media.

Technology Process of Bis-PEG13-PFP ester

There total 1 articles about Bis-PEG13-PFP ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxatritetracontanedioic acid (1053656-79-3) + 2,3,4,5,6-pentafluorophenol (771-61-9) → PfpOOC-CH2CH2O(CH2CH2O)12CH2CH2-COOPfp (1383567-59-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 ℃; for 1.5h;

DOI:10.1002/psc.2416

Reference yield:

PfpOOC-CH2CH2O(CH2CH2O)12CH2CH2-COOPfp (1383567-59-6) + N-butylamine (109-73-9,85404-21-3) → PfpOOC-CH2CH2O(CH2CH2O)12CH2CH2-CONHC4H9 (1383567-61-0)

Guidance literature:

In N,N-dimethyl-formamide; for 1.5h;

DOI:10.1002/psc.2416

upstream raw materials:

4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxatritetracontanedioic acid

2,3,4,5,6-pentafluorophenol

Downstream raw materials:

PfpOOC-CH₂CH₂O(CH₂CH₂O)12CH₂CH₂-CONHC₄H₉