4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

Base Information

Chemical Name:4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid
CAS No.:75174-46-8
Molecular Formula:C₂₄H₄₀N₂O₄S
Molecular Weight:452.659
Hs Code.:

Synonyms:4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

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Chemical Property of 4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

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Technology Process of 4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

There total 3 articles about 4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 75161-21-6
2-Methyl-3-ethyl-4-amino-thiomorpholin-S-dioxid

: 75161-56-7
4-Hydroxy-2,5-di-tert-butyl-phenyl-propionylchlorid

: 75174-46-8
4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 6h;
DOI:10.1007/BF00903234

Reference yield:

: 41493-14-5
2-Methyl-3-ethyl-thiomorpholin-S-dioxid

: 75174-46-8
4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaNO₂, conc. HCl / H₂O / 1.) 5 h, 80-85 deg C, 2.) 12 h, room temperature

2: 1.) NH₄OAc, Ac₂O, AcOH, Zn, 2.) HCl, H₂O / 1.) 100-115 deg C, 2.) 2 h, reflux

3: 63 percent / Et₃N / CH₂Cl₂ / 6 h / 0 °C

With hydrogenchloride; ammonium acetate; water; acetic anhydride; acetic acid; triethylamine; zinc; sodium nitrite; In dichloromethane; water;
DOI:10.1007/BF00903234

Reference yield:

: 75161-19-2
2-Methyl-3-ethyl-4-nitroso-thiomorpholin-S-dioxid

: 75174-46-8
4-(4-Hydroxy-2,5-di-tert-butyl-phenyl-propionyl-amino)-2-methyl-3-ethyl-thiomorpholin-1,1-dioxid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NH₄OAc, Ac₂O, AcOH, Zn, 2.) HCl, H₂O / 1.) 100-115 deg C, 2.) 2 h, reflux

2: 63 percent / Et₃N / CH₂Cl₂ / 6 h / 0 °C

With hydrogenchloride; ammonium acetate; water; acetic anhydride; acetic acid; triethylamine; zinc; In dichloromethane;
DOI:10.1007/BF00903234