4-amino-4-dihydrospectinomycin

Base Information

• Chemical Name: 4-amino-4-dihydrospectinomycin
• CAS No.: 72748-69-7
• Molecular Formula: C₁₄H₂₇N₃O₆
• Molecular Weight: 333.385
• Mol file: 72748-69-7.mol

Synonyms:2H-Pyrano[2,3-b][1,4]benzodioxin-4a,7,9(10aH)-triol,4-aminooctahydro-2-methyl-6,8-bis(methylamino)-, [2R-(2a,4a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]-; 4-Spectinomycylamine II

Chemical Property of 4-amino-4-dihydrospectinomycin

Chemical Property:

• Vapor Pressure: 2.7E-15mmHg at 25°C
• Boiling Point: 568.6°C at 760 mmHg
• Flash Point: 297.7°C
• PSA: 138.46000
• Density: 1.39g/cm³
• LogP: -1.68530

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-4-dihydrospectinomycin

There total 4 articles about 4-amino-4-dihydrospectinomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-bis(N-tert-butyloxycarbonyl)spectinomycin → C14H27N3O6 + C14H27N3O6 (72748-69-7)

Guidance literature:

1,3-bis(N-tert-butyloxycarbonyl)spectinomycin; With ammonium nitrate; acetic acid; In methanol; at 20 ℃; for 3h;

With triethylamine-borane; In methanol; at -10 - 20 ℃; for 16h; Reagent/catalyst; Solvent; Overall yield = 70 percent; diastereoselective reaction;

DOI:10.1021/jacs.9b13766

Reference yield:

1,3-bis(N-tert-butyloxycarbonyl)-3'-benzyloximespectinomycin → C14H27N3O6 + C14H27N3O6 (72748-69-7)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In ethanol; water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.9b13766

Reference yield:

spectinomycin dihydrochloride → C14H27N3O6 (72748-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran; acetone / 24 h / 40 °C

2.1: acetic acid; ammonium nitrate / methanol / 3 h / 20 °C

2.2: 16 h / -10 - 20 °C

With ammonium nitrate; acetic acid; triethylamine; In tetrahydrofuran; methanol; acetone;

DOI:10.1021/jacs.9b13766

Refernces