(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

Base Information

Chemical Name:(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone
CAS No.:1026478-79-4
Molecular Formula:C₄₆H₄₇NO₉
Molecular Weight:757.88
Hs Code.:

(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

Synonyms:(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

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Chemical Property of (4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

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Technology Process of (4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

There total 1 articles about (4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 403656-66-6
(4R)-4-(diphenylmethyl)-3-[(3R)-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)]butanoyl-2-oxazolidinone

: 1026478-79-4
(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

Guidance literature:: (4R)-4-(diphenylmethyl)-3-[(3R)-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)]butanoyl-2-oxazolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.25h; Further stages.;
DOI:10.1021/jo015501x

Reference yield: 74.0%

: 1026478-79-4
(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

: 1026565-45-6
(2R,3R)-2-[(3'-methoxy-4'-benzyloxyphenyl)methyl]-3-[(3',4'-dimethoxyphenyl)methyl]-succinic-acid-4-ethyl-ester

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 3h;
DOI:10.1021/jo015501x

Reference yield:

: 1026478-79-4
(4R)-4-(diphenylmethyl)-3-[(2R,3R)-2-(3'-methoxy-4'-benzyloxyphenyl)methyl-3-(ethoxycarbonyl)-4-(3',4'-dimethoxyphenyl)methyl]butanoyl-2-oxazolidinone

: 87605-56-9,87678-76-0
(3R,4R)-3-[(3-methoxy-4-hydroxyphenyl)methyl]-4-[(3,4-dimethoxyphenyl)methyl]dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 74 percent / LiOH*H₂O; H₂O₂ / tetrahydrofuran; H₂O / 3 h / 0 °C

2.1: LiBH₄ / tetrahydrofuran / Heating

2.2: MeOH / tetrahydrofuran / 2 h / Heating

3.1: 41 mg / pyridinium p-toluenesulfonate / benzene / Heating

4.1: 75 percent / H₂ / 10percent Pd/C / ethyl acetate; acetic acid / 1.5 h

With lithium hydroxide; lithium borohydride; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; 10percent Pd/C; In tetrahydrofuran; water; acetic acid; ethyl acetate; benzene;
DOI:10.1021/jo015501x