3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

Base Information

Chemical Name:3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile
CAS No.:1155846-77-7
Molecular Formula:C₁₉H₁₁Cl₂N₅O₂
Molecular Weight:412.235
Hs Code.:

Synonyms:3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

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Chemical Property of 3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

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Technology Process of 3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

There total 11 articles about 3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1155847-48-5
3-chloro-5-[(4-chloro-2-hydroxypyridin-3-yl)oxy]benzonitrile

: 174180-76-8
3-bromomethylpyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester

: 1155846-77-7
3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

Guidance literature:: 3-chloro-5-[(4-chloro-2-hydroxypyridin-3-yl)oxy]benzonitrile; 3-bromomethylpyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 1h;

With trifluoroacetic acid; at 19 - 26 ℃; for 0.25h;

Reference yield:

: 1155847-46-3
3-[(2-amino-4-chloropyridin-3-yl)oxy]-5-chlorobenzonitrile

: 1155846-77-7
3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; sodium nitrite

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 55 °C

3: trifluoroacetic acid

With sulfuric acid; potassium carbonate; trifluoroacetic acid; sodium nitrite; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.027

Reference yield:

: 1155847-48-5
3-chloro-5-[(4-chloro-2-hydroxypyridin-3-yl)oxy]benzonitrile

: 1155846-77-7
3-chloro-5-{[4-chloro-2-oxo-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 55 °C

2: trifluoroacetic acid

With potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.027