3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide

Base Information

• Chemical Name: 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide
• CAS No.: 1228284-73-8
• Molecular Formula: C₁₇H₁₈Cl₃F₂N₃O₂
• Molecular Weight: 440.705
• Mol file: 1228284-73-8.mol

Synonyms:3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide

Chemical Property of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide

There total 7 articles about 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride (141573-96-8) + O-methyl-N-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-hydroxylamine (1228284-83-0) → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide (1228284-73-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

N-methoxy-N-methyl-3-(2,4,6-trichloro-phenyl)-propionamide (1191993-11-9) → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide (1228284-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C

2: triethylamine / methanol / 3 h / 60 °C

3: sodium cyanoborohydride; acetic acid / 6 h / 20 °C

4: triethylamine / dichloromethane / 18 h / 0 - 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

4-(2,4,6-trichloro-phenyl)-butan-2-one O-methyl-oxime (1228284-99-8) → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-amide (1228284-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / 6 h / 20 °C

2: triethylamine / dichloromethane / 18 h / 0 - 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; In dichloromethane;

upstream raw materials:

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride

O-methyl-N-[1-methyl-3-(2,4,6-trichloro-phenyl)-propyl]-hydroxylamine

2,4,6-trichlorobenzaldehyde

3-(2,4,6-trichlorophenyl)propanoic acid