1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

Base Information

Chemical Name:1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid
CAS No.:1229236-34-3
Molecular Formula:C₁₈H₁₅F₂NO₂
Molecular Weight:315.319
Hs Code.:

Synonyms:1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

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Technology Process of 1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

There total 2 articles about 1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-(3,4-difluoro-phenyl)-propynoic acid ethyl ester: 1229236-35-4
3-(3,4-difluoro-phenyl)-propynoic acid ethyl ester

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 1229236-34-3
1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

Guidance literature:: 3-(3,4-difluoro-phenyl)-propynoic acid ethyl ester; N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 18h;

With hydrogenchloride; In water; at 20 ℃; for 48h;

Reference yield:

: 1229236-34-3
1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

Guidance literature:

Reference yield: 88.0%

: 1229236-34-3
1-benzyl-4-(3,4-difluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid

: 1229236-28-5
(3S,4S)-1-Benzyl-4-(3,4-difluoro-phenyl)-pyrrolidine-3-carboxylic acid

Guidance literature:: With hydrogen; triethylamine; [Ru(OAc)2((R)-2-Furyl-MeOBIPHEP)]; In methanol; at 30 ℃; for 20h; under 30003 Torr; Product distribution / selectivity; Inert atmosphere;