(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

Base Information

Chemical Name:(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone
CAS No.:221344-88-3
Molecular Formula:C₁₇H₂₈N₂O₃S
Molecular Weight:340.487
Hs Code.:

Synonyms:(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

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Chemical Property of (2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

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Technology Process of (2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

There total 1 articles about (2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90020-41-0
(1E)-3-methylbut-1-en-1-yl phenyl sulfone

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: (2S,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

: 221344-88-3
(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

Guidance literature:: With ytterbium(III) triflate; In tetrahydrofuran; for 72h; Yield given; Yields of byproduct given; Heating;
DOI:10.1002/(sici)1521-3773(19990115)38:1/2<195::aid-anie195>3.0.co;2-6

Reference yield:

: 221344-88-3
(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

: (R)-2-(tert-butoxycarbonylamino)-3-methylbutyl phenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1: BH₃*THF / tetrahydrofuran / 5 h / Heating

2: 1.38 g / Et₃N / methanol / 48 h / 20 °C

With borane-THF; triethylamine; In tetrahydrofuran; methanol; 1: Reduction / 2: Acylation;
DOI:10.1002/(sici)1099-0690(200003)2000:6<879::aid-ejoc879>3.0.co;2-e

Reference yield:

: 221344-88-3
(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]-3-methylbutyl phenyl sulfone

: 221344-97-4
(R)-2-amino-3-methylbutyl phenyl sulfone

Guidance literature:: With hydrogenchloride; boron trifluoride-tetrahydrofuran complex; water; Multistep reaction; 1.) THF, reflux, 5 h, 2.) THF, r.t., 2 h;
DOI:10.1002/(sici)1521-3773(19990115)38:1/2<195::aid-anie195>3.0.co;2-6