(4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

Base Information

Chemical Name:(4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline
CAS No.:1253265-44-9
Molecular Formula:C₂₂H₃₂N₂O₅S
Molecular Weight:436.572
Hs Code.:

Synonyms:(4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

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Chemical Property of (4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

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Technology Process of (4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

There total 1 articles about (4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1253265-82-5
(4S,4aR,8aS)-4-(azidomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

: 1253265-44-9
(4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;
DOI:10.1002/chem.201000421

Reference yield: 43.0%

: 1253265-44-9
(4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline

: 1253265-46-1
(4S,4aR,6S,7S,8aS)-4-[2-(1,3-dioxolan-2-yl)ethyl]-7-hydroxy-6,4-(iminomethano)-2-(p-methoxybenzenesulfonyl)perhydroisoquinoline

Guidance literature:: (4S,4aR,8aS)-4-(aminomethyl)-4-[2-(1,3-dioxolan-2-yl)ethyl]-2-(p-methoxybenzenesulfonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline; With mercury(II) trifluoroacetate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With sodium chloride; In dichloromethane; water; for 1h;

With sodium tetrahydroborate; oxygen; In 1,1,1,3',3',3'-hexafluoro-propanol; for 3.5h;
DOI:10.1002/chem.201000421